What causes Cold Agglutinin Disease?
CAD, also known as primary chronic CAD, is a rare and serious autoimmune hemolytic condition with systemic acute and chronic consequences. Hemolysis in CAD is dependent on classical complement pathway activation.1,2
Unlike cold agglutinin syndrome (CAS), CAD is not caused by malignancy or acute infection.3
CAD comprises approximately 20% of all types of AIHA.4 Based on a population study, CAD affects up to 16 people per 1,000,000 with an average age of onset of 60 years, although onset of CAD has been seen in some patients as young as 30 years.1
Find out more about what CAD is here.