Frequently Asked Questions

Is Cold Agglutinin Disease cancer?

No. CAD is a chronic condition characterized by autoimmune hemolytic anemia.¹

Unlike Cold Agglutinin Syndrome (CAS), CAD, also known as primary chronic CAD, is a rare and serious autoimmune hemolytic condition with systemic acute and chronic consequences. Hemolysis in CAD is dependent on classical complement pathway activation.²

Find out more about the mechanism of CAD here.

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CAD=Cold Agglutinin Disease.

References: 1. Berentsen S, Tjønnfjord GE. Diagnosis and treatment of cold agglutinin mediated autoimmune hemolytic anemia. Blood Rev. 2012;26(3):107-115. 2. Berentsen S, Beiske K, Tjønnfjord GE. Primary chronic cold agglutinin disease: an update on pathogenesis, clinical features and therapy. Hematology. 2007;12(5):361-370.