Frequently Asked Questions

Is Cold Agglutinin Disease cancer?

No. CAD is a chronic condition characterized by autoimmune hemolytic anemia.1

Unlike Cold Agglutinin Syndrome (CAS), CAD, also known as primary chronic CAD, is a rare and serious autoimmune hemolytic condition with systemic acute and chronic consequences. Hemolysis in CAD is dependent on classical complement pathway activation.2

CAD=Cold Agglutinin Disease.
References: 1. Berentsen S, Tjønnfjord GE. Diagnosis and treatment of cold agglutinin mediated autoimmune hemolytic anemia. Blood Rev. 2012;26(3):107-115. doi:10.1016/j.blre.2012.01.002 2. Berentsen S, Beiske K, Tjønnfjord GE. Primary chronic cold agglutinin disease: an update on pathogenesis, clinical features and therapy. Hematology. 2007;12(5):361-370. doi:10.1080/10245330701445392