Frequently Asked Questions

What are the most common signs and symptoms of Cold Agglutinin Disease?

The disease course of Cold Agglutinin Disease is unpredictable and presents with an array of signs and symptoms that vary for every patient. Some of the most common signs and symptoms of CAD are1-3:

  • Hemolytic anemia
  • Shortness of breath
  • Jaundice
  • Fatigue
  • Dark urine
  • Cold-induced acrocyanosis

The above are some of the more common signs and symptoms, but patients may experience others— that’s why it’s so important to understand how to accurately diagnose CAD.

CAD=Cold Agglutinin Disease.
References: 1. Mullins M, Jiang X, Bylsma LC, et al. Cold agglutinin disease burden: a longitudinal analysis of anemia, medications, transfusions, and health care utilization. Blood Adv. 2017;1(13):839-848. 2. Aljubran SA. Cold agglutinin disease clinical presentation. Medscape website. emedicine.medscape.com/article/135327-clinical. Updated August 28, 2018. Accessed April 19, 2019. 3. Hill QA, Stamps R, Massey E, et al; on behalf of the British Society for Haematology. The diagnosis and management of primary autoimmune haemolytic anaemia. Br J Haematol. 2017;176(3):395-411.