Frequently Asked Questions

Is Cold Agglutinin Disease hereditary?

CAD is not a hereditary disease.1 CAD is a rare disease, and, to be accurately diagnosed, 3 main criteria must be met2-4:

  1. 1. Evidence of hemolysis.
  2. 2. Positive Coombs test results (direct antibody test) for C3d.
  3. 3. Presence of Cold Agglutinin Titer ≥1:64.

Unlike CAS, CAD is not secondary to cancer or an acute infection.

CAD=Cold Agglutinin Disease; CAS=cold agglutinin syndrome.
References: 1. Cold agglutinin disease. Genetic and Rare Diseases Information Center (GARD). Accessed June 10, 2021. 2. Berentsen S, Tjønnfjord GE. Diagnosis and treatment of cold agglutinin mediated autoimmune hemolytic anemia. Blood Rev. 2012;26(3):107-115. doi:10.1016/j.blre.2012.01.002 3. Hill QA, Stamps R, Massey E, Grainger JD, Provan D, Hill A; British Society for Haematology. The diagnosis and management of primary autoimmune haemolytic anaemia. Br J Haematol. 2017;176(3):395-411. doi:10.1111/bjh.14478. 4. Swiecicki PL, Hegerova LT, Gertz MA. Cold agglutinin disease. Blood. 2013;122(7):1114-1121. doi:10.1182/blood-2013-02-474437