Frequently Asked Questions

Is Cold Agglutinin Disease hereditary?

CAD is not a hereditary disease.1 CAD is a rare disease and to be accurately diagnosed, 3 main criteria must be met2-4:

  1. 1. Evidence of hemolysis.
  2. 2. Positive Coombs test results (direct antibody test) for C3d.
  3. 3. Presence of cold agglutinin titer ≥1:64.

Unlike CAS, CAD is not secondary to cancer or an acute infection.

CAD=Cold Agglutinin Disease; CAS=cold agglutinin syndrome.
References: 1. Cold agglutinin disease. Genetic and Rare Diseases Information Center (GARD) — an NCATS Program. https://rarediseases.info.nih.gov/diseases/6130/cold-agglutinin-disease#ref_7407. Accessed October 31, 2019. 2. Berentsen S, Tjønnfjord GE. Diagnosis and treatment of cold agglutinin mediated autoimmune hemolytic anemia. Blood Rev. 2012;26(3):107-115. 3. Hill QA, Stamps R, Massey E, et al; on behalf of the British Society for Haematology. The diagnosis and management of primary autoimmune haemolytic anaemia. Br J Haematol. 2017;176(3):395-411. 4. Swiecicki PL, Hegerova LT, Gertz MA. Cold agglutinin disease. Blood. 2013;122(7):1114-1121.